England utility back Iain Balshaw will replace Jason Robinson at fullback when the Roses host Wales at Twickenham.
Mathew Tait was expected to move to fullback for Saturday’s Six Nations opener but has instead been replaced by Mike Tindall at centre. Seven changes in all are made to the team who lost 15-6 to the Springboks in last year’s World Cup final.
Gloucester loose forward Luke Narraway will make his debut at No 8 while Tongan-born Lesley ‘Volcano’ Vanikolo will start on the bench. James Haskell replaces the retired Martin Corry and Steve Borthwick takes Ben Kay’s spot at lock.
The backline sees Toby Flood inside Tindall while David Strettle replaces Mark Cueto on the wing.
England – Iain Balshaw (Gloucester), Paul Sackey (Wasps), Mike Tindall (Gloucester), Toby Flood (Newcastle), David Strettle (Harlequins), Jonny Wilkinson (Newcastle), Andy Gomarsall (Harlequins); Andrew Sheridan (Sale), Mark Regan (Bristol), Phil Vickery (Wasps), Simon Shaw (Wasps), Steve Borthwick (Bath), James Haskell (Wasps), Lewis Moody (Leicester), Luke Narraway (Gloucester).
Subs: Lee Mears (Bath), Matt Stevens (Bath), Ben Kay (Leicester), Tom Rees (Wasps), Richard Wigglesworth (Sale), Dan Cipriani (Wasps), Lesley Vainikolo (Gloucester).