Sharks flyhalf Frederick Michalak is set to play off the bench when France tackle Argentina in Cordoba on Saturday.
Michalak will provide cover for first-choice pivot Francois Trinh-Duc.
Other selections will see fullback Brice Dulin and loosehead prop Yvan Watremez make their Test debuts in the starting line-up. There are three other uncapped players on the bench, with hooker Christopher Tolofua, lock Romain Taofifenua and scrumhalf Maxime Machenaud expected to make their first international appearances as reserves.
This will be the first of a two-Test series.
France - 15 Brice Dulin, 14 Jean-Marcellin Buttin, 13 Wesley Fofana, 12 Florian Fritz, 11 Yoann Huget, 10 Francois Trinh-Duc, 9 Morgan Parra, 8 Fulgence Ouedraogo, 7 Louis Picamoles, 6 Wenceslas Lauret, 5 Yoann Maestri, 4 Pascal Pape (c), 3 David Attoub, 2 Dimitri Szarzewski, 1 Yvan Watremez.
Subs: 16 Christopher Tolofua, 17 Vincent Debaty, 18 Romain Taofifenua, 19 Alexandre Lapandry, 20 Maxime Machenaud, 21 Frederic Michalak, 22 Maxime Mermoz.