Ireland captain Brian O’Driscoll and Ulster hooker Rory Best won’t play against the Springboks.
Both are out of the entire Autumn internationals because of injury.
It means South African-born former Cheetahs hooker Richardt Strauss is likely to debut for Ireland against the Boks.
And to add spice to the occasion he will probably start against his cousin Adriaan Strauss.
Strauss, who has been playing for Leinster for the last three seasons, told SA Rugby Magazine, that he would have no mixed emotions playing against the Boks.
‘I had a great time in South Africa. Now I am having a great time in Ireland,’ said Strauss.
O’Driscoll hurt his ankle against Cardiff and will required surgery which rules him out for 8-12 weeks.
Best sprained ligaments in his neck and is out for six weeks.
The Boks start their three-Test tour against Ireland in Dublin, having won just one of their last four Tests in Dublin.
The positive is the victory came in their most recent visit when they triumphed 23-21 in 2010.