The Lions started their season with a 51-13 thrashing of Russia at Ellis Park on Saturday having led 20-3 at the break.
The hosts crossed the whitewash on five occasions, and were also awarded two penalty tries.
Flyhalf Lionel Cronje had an impressive outing with the boot in his debut for the Johannesburg side as he slotted five conversions and two penalties.
In reply, Russia only managed a consolation try via Alexey Makovetskiy in the second half. Their poor discipline saw Valeriy Tsnobiladze yellow carded for a breakdown transgression, while Igor Klyuchnikov received a late red card for a dangerous tackle.
The Lions face the Cheetahs and Bulls over the next two weekends, before taking on the Kings on 9 February.