Scotland will tour South Africa with nine uncapped players.
Scotland have lost three players to the British and Irish Lions tour of Australia, and another handful of Six Nations regulars have been rested for the Tests in South Africa in June.
Acting head coach Scott Johnson said the purpose of the tour was to build squad depth and expose more players to international rugby.
The Boks play Scotland and Italy in a quadrangular that also involves Samoa.
Backs: Alex Dunbar (Glasgow Warriors), Tom Heathcote (Bath), Peter Horne, Ruaridh Jackson (both Glasgow Warriors), Greig Laidlaw (Edinburgh), Sean Lamont, Peter Murchie, Henry Pyrgos (all Glasgow Warriors), Matt Scott (Edinburgh), Tommy Seymour (Glasgow Warriors), Duncan Taylor (Saracens), Greig Tonks and Tim Visser (both Edinburgh).
Forwards: John Barclay (Glasgow Warriors), Johnnie Beattie (Montpellier), Kelly Brown (Saracens, captain), Geoff Cross, David Denton (both Edinburgh), Alasdair Dickinson (Sale Sharks), Ross Ford, Grant Gilchrist (both Edinburgh), Ryan Grant (Glasgow Warriors), Jim Hamilton (Gloucester), Alastair Kellock (Glasgow Warriors), Steven Lawrie (Edinburgh), Moray Low, Pat MacArthur (both Glasgow Warriors), Euan Murray (Worcester Warriors), Alasdair Strokosch (Perpignan), Tim Swinson and Ryan Wilson (both Glasgow Warriors).