Marcel Coetzee will start for the Springboks in place of Francois Louw, who is getting married on Saturday.
Coetzee is the only change among the forwards and veteran scrumhalf Ruan Pienaar will take over from the injured Jano Vermaak. Francois Hougaard has also been ruled out and Piet van Zyl will be among the substitutes.
Arno Botha, excellent against Italy, will retain his place ahead of Willem Alberts, who continues to battle with niggling injuries.
The match squad will be named later on Wednesday.