Bath will have to play their final five matches of 2017-18 without Anthony Watson, who has been ruled out with an Achilles injury.
Set to join Toulon at the end of the season, injury looks to have ended Rhys Webb's time in Welsh rugby.
Having struggled for game time at Sale Sharks, Josh Charnley has moved back to rugby league and joined Warrington Wolves.
Karmichael Hunt can return for the Reds and and his country after Rugby Australia (RA) completed its investigation.
Jonathan Sexton says the retirement of Jamie Heaslip will make him savour Ireland's Grand Slam triumph all the more.