Leinster suffered a surprise Pro14 defeat against Ospreys on Saturday, while Cardiff Blues won for a fifth game in a row.
Montpellier ran in five tries to claim a bonus-point victory over Castres, maintaining their position as Top 14 leaders.
A club-record crowd of 30,174 witnessed Newcastle Falcons win at St James' Park as Toby Flood kicked 20 points against Northampton.
Despite Filipo Daugunu's stunning solo try, the Reds saw their comeback bid fall short as the Stormers triumphed in Cape Town.
The Jaguares beat the Lions 49-35 in Buenos Aires and the Stormers beat the Reds 25-19 in Cape Town. Get all the details from...
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Super Rugby's last unbeaten run has been broken after the Hurricanes got the better of the Highlanders.