Dylan Hartley is "feeling a lot better" and is looking forward to resuming his career for club and country.
Eddie Jones has been forced to bring in three replacements for the upcoming series against the Springboks.
France internationals Yoann Maestri and Gael Fickou have swapped Toulouse for long-term deals at Stade Francais.
Toulon have lost experienced centre Ma'a Nonu, who will put his career on hold due to "family reasons".
After being deemed to have fielded ineligible players, Romania and Spain have appealed against Rugby World Cup qualifying sanctions.
Eddie Jones is confident England will have "opportunities" to create history in South Africa.
After handing captain Brad Barritt a new contract this week, Saracens have tied director of rugby Mark McCall down to a new deal.