Beauden Barrett will not be risked for the third Test against France, but Ricky Riccitelli and Jackson Hemopo could win their first caps.
England have confirmed Billy Vunipola re-fractured his right arm during the second Test against the Springboks.
Argentina are on the look-out for a new coach ahead of next Saturday's meeting with Scotland, after Daniel Hourcade resigned.
South Africa made a slow start against England but, to Rassie Erasmus' delight, came roaring back to clinch the series.
England let a 12-0 lead slip to lose to South Africa on Saturday, leading captain Owen Farrell to conclude that his side lack composure.
Scotland became the first tier-one nation to be defeated by USA after a 30-29 loss in Houston on Saturday.