Montpellier put Toulouse to the sword, Piula Faasalele's dismissal proving to be costly as last year's runners-up scored 10 tries.
Leicester Tigers produced a storming second-half fightback but Ted Hill's late try gave Worcester Warriors a first win of the season.
South Africa coach Rassie Erasmus has increased his options ahead of home Tests against Australia and New Zealand.
Saracens scrum-half Richard Wigglesworth is set to become the Premiership's all-time record appearance holder – here are his best stats.