Joey Carbery, Rory Scannell, Keith Earls and Andrew Conway were among the tries as Munster overpowered Gloucester.
Returning to action after a broken arm proved an anxious experience for Saracens' Billy Vunipola, who is steadily regaining his poise.
Bill Beaumont, chairman of World Rugby, hailed the progress made on injury-prevention in the sport but acknowledged more needs to be done.
Three weeks before the start of the Six Nations, Sam Underhill has been ruled out of the tournament in a significant blow to England.