Northampton scored 17 tries in a record victory as they beat Timisoara Saracens 111-3 to reach the European Challenge Cup quarter-finals.
Both Edinburgh and Glasgow Warriors are through to the European Champions Cup quarter-finals due to the former's 19-10 win over Montpellier.
Billy Vunipola will take more motivation from England's response to the 2015 Rugby World Cup than from the disappointment.
Cheetahs secured a dramatic 24-17 victory over South African rivals Southern Kings after Luan de Bruin touched down in the 85th minute.