Zack Holmes scored 15 points as Toulouse extended their lead at the Top 14 summit, while Stade Francais boosted their play-off hopes.
Luca Sperandio and Niccolo Cannone scored two tries apiece as Benetton Treviso stretched their unbeaten run to eight games.
Warren Gatland hailed his “special” Wales players after they claimed a record 12th consecutive win at the expense of England.
England’s defeat to Wales in the Six Nations was decided by “small margins” and their ill-discipline proved costly, says Eddie Jones.
There was late drama for the Stormers against the Lions, while the Sharks were decidedly more comfortable against the Blues in Super Rugby.
Wales came from 10-3 down at half-time to claim a record 12th consecutive victory and go top of the Six Nations table.
Saracens’ defeat on Friday left the door ajar for Exeter Chiefs, who downed Newcastle Falcons to go top of the Premiership.
Having been thrashed by England last time out, a much-changed France side produced a fine showing to down Scotland in Paris.
Peter O’Mahony is relishing the prospect of leading Ireland out in Rome in the absence of the rested Rory Best.
New Zealand pair Richie Mo’unga and Scott Barrett scored two tries each in a convincing win for the Crusaders.