La Rochelle put Pau to the sword and Castres also enhanced their chances of reaching the play-offs with a win in Bordeaux.
Glasgow Warriors celebrated the news that head coach Dave Rennie will stay at the club by securing a famous win over Leinster in Dublin.
Worcester Warriors and Bristol Bears eased their relegation fears, leaving Newcastle Falcons needing a great escape to avoid the drop.
The Sharks gave another demonstration of their inconsistent at Kings Park, where the Jaguares ran riot with a seven-try drubbing.
Lachlan Boshier crossed twice as the Chiefs overcame the Blues in Hamilton. In Canberra, the Brumbies were 31-20 winners over the Lions.