Toulouse booked their place in a Top 14 final for the first time since 2012 after they overcame La Rochelle in Bordeaux.
Sebastian Cancelliere and Emiliano Boffelli each scored two tries apiece as the Jaguares wrapped up a deserved win against the Sharks.
The Lions are used to reaching the Super Rugby showpiece match but a 37-17 defeat to the Hurricanes has endangered their play-off hopes
The Crusaders ensured they will finish top of the table in Super Rugby after battering the Rebels on Saturday.