England must show they have a mature mentality if they are to defeat Scotland and clinch the Calcutta Cup, says Courtney Lawes.
Dewi Lake and Taine Basham will be hoping to make their Wales debuts against Ireland after they were called up to the squad.
Ireland's James Ryan is hungry for more honours with club and country after signing a new deal.
England will again have to cope without Anthony Watson as they look to bounce back from defeat to France in their Six Nations opener.
Defending champions Wales will have to do without Liam Williams for at least another two Six Nations matches.
Injuries sustained by Garry Ringrose and Caelan Doris open the door for Robbie Henshaw and Peter O'Mahony to start against Wales.
Eddie Jones confirmed Manu Tuilagi will not face Scotland, but is hopeful the centre will take on Ireland at Twickenham.
Tom Curry looks certain to continue at number eight for the foreseeable future and earned the backing of England coach Eddie Jones.
In-form Harlequins number eight Alex Dombrandt will play no part in the Calcutta Cup clash after being left out of England's squad.
Gregor Townsend said the door is open for Finn Russell to return to the Scotland squad, but he will not face England.
Ahead of crunch Six Nations matches with Wales and England, Ireland were dealt a blow with Garry Ringrose ruled out.
Man-of-the-match Gregory Alldritt said France were determined to show Eddie Jones they have fighting spirit in Paris.
Harlequins captain Chris Robshaw has announced he will leave the club and move on to pastures new at the end of the season.
New head coach Fabien Galthie believes France reaped the rewards of meticulous preparation for the Six Nations when they beat England.
England were made to pay for an error-strewn performance in Paris, where France enjoyed a winning start to the Six Nations.
After England coach Eddie Jones questioned their Test credentials ahead of the Six Nations clash, France let their rugby do the talking.