Wales came from 10-3 down at half-time to claim a record 12th consecutive victory and go top of the Six Nations table.
Saracens' defeat on Friday left the door ajar for Exeter Chiefs, who downed Newcastle Falcons to go top of the Premiership.
Having been thrashed by England last time out, a much-changed France side produced a fine showing to down Scotland in Paris.
Peter O'Mahony is relishing the prospect of leading Ireland out in Rome in the absence of the rested Rory Best.
New Zealand pair Richie Mo'unga and Scott Barrett scored two tries each in a convincing win for the Crusaders.
Ben Morgan's brace led Gloucester to another big victory as they fended off a fast-finishing Saracens.
Glasgow Warriors closed the gap on Munster at the top of Conference A, despite both recording wins in the latest round of Pro14 fixtures.
Wales full-back Leigh Halfpenny will play for the first time since November when the Scarlets take on the Cheetahs.
Sean Cronin has come off the bench 32 times for Ireland in the Six Nations, but he will start in Rome this weekend.
Sonny Bill Williams' future is once again a major talking point and Toronto Wolfpack are willing to spend big to secure the cross-code star.
Warren Gatland says it will be a "big challenge" for Kyle Sinckler to avoid getting in hot water at the Principality Stadium.
Eddie Jones says only Manu Tuilagi can decide his future amid reports he is set for a big-money move to the Top 14.
The Reds threatened to upset the Highlanders in their Super Rugby opener, but Aaron Mauger's men made it two wins out of two.
The third round of fixtures in the 2019 Six Nations sees Wales host England, Scotland visit France, and Ireland head to Italy.
Eddie Jones described Warren Gatland's team as "the greatest Welsh side ever", but the Wales coach does not agree.
Gareth Anscombe gets the nod at number 10 in a much-changed Wales side for a huge encounter with England.