Lyon scored all five tries in the second half in a rout of Stade Francais, while Racing 92 claimed their fourth consecutive win.
Eddie Jones backed Owen Farrell after England's narrow victory against South Africa.
Clermont Auvergne could only draw with lowly Grenoble and Toulouse took advantage by putting Bordeaux-Begles to the sword in the Top 14.
Jordan Larmour grasped his first opportunity to start for Ireland with both hands, scoring three tries and laying on another in Chicago.
Warren Gatland saw room for improvement but was encouraged by the way Wales saw off Scotland to win the Doddie Weir Cup.
There were wins for Connacht and Ulster in Saturday's Pro14 action.
South Africa dominated England in the second half, but Eddie Jones was pleased with the way his side hung in there and fought back.
South Africa paid the price for letting England off the hook at Twickenham, where Eddie Jones' men gained revenge for a series loss in...
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Wales started their November internationals with victory over Scotland, Jonathan Davies scoring on his return from a long injury lay-off.
Jordie Barrett made another mistake in the All Blacks' win over Japan, but Steve Hansen came to his defence.
Glasgow Warriors stretched their lead at the top of Conference A to nine points thanks to Nikola Matawalu's hat-trick against Ospreys.
Beauden Barrett will make history if he is named the best player in the world again, but he has some strong competition.
Manu Tuilagi has suffered yet another injury blow, a groin problem ruling him out of the showdown with South Africa.
Both Ireland and Italy are lacking several key men for this weekend's Test meeting in the United States.
Injuries have ravaged England's forward pack, but Eddie Jones is excited and confident heading into the South Africa Test.
Rassie Erasmus has made seven changes to his South Africa side, bringing in Ivan van Zyl as well as regulars including Warren Whiteley.