Seven uncapped players will be given the chance to impress Rassie Erasmus when South Africa face Wales in Washington on Saturday.
Dylan Hartley is "feeling a lot better" and is looking forward to resuming his career for club and country.
France internationals Yoann Maestri and Gael Fickou have swapped Toulouse for long-term deals at Stade Francais.
Toulon have lost experienced centre Ma'a Nonu, who will put his career on hold due to "family reasons".
After being deemed to have fielded ineligible players, Romania and Spain have appealed against Rugby World Cup qualifying sanctions.
Eddie Jones is confident England will have "opportunities" to create history in South Africa.
After handing captain Brad Barritt a new contract this week, Saracens have tied director of rugby Mark McCall down to a new deal.
Brive have announced the signing of Stuart Olding, who was released by Ulster last month despite his acquittal in a rape trial.
History will be made when Stormers flanker Siya Kolisi leads the Springboks in three home Tests against England in June.
Toulouse's Richie Gray has joined Alex Dunbar in pulling out of the Scotland squad for their June fixtures.
Saracens have announced a new contract for skipper Brad Barritt, who is staying with the club for at least the next two seasons.
Jared Payne has ended his playing career on medical advice and will take up a role as defence coach at Ulster.
Wales will have to do without Aaron Shingler and Ashton Hewitt when they come up against the Springboks and the Pumas in June.
World Rugby's proposed new law to protect players in the tackle has been endorsed by All Blacks coach Steve Hansen.
Victory over the Scarlets saw Leinster become the first team to combine European Champions Cup success with the Pro14 title.
The Lions and the Brumbies both grabbed late victories as a pair of red cards had a big say on two tense Super Rugby...
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