Eddie Jones apologised to England fans after their Six Nations Grand Slam hopes went up in smoke at Murrayfield against an inspired Scotland
Agen and Oyonnax secured rare wins at the foot of Top 14, while Montpellier enjoyed another successful day at the top.
Leinster's big win on Saturday did not quell Scarlets as they kept pace in the Pro14, while Benetton Treviso's promising form was ended.
Warren Gatland dismissed Wales' Six Nations chances after losing in Ireland and will look to blood new players into the team next time out.
Star performances from Aphiwe Dyantyi and Pierre Schoeman earned victories for the Lions and the Bulls in Saturday's Super Rugby action.
John Barclay hailed Finn Russell as one of the best fly-halves in world rugby after he inspired Scotland to a stunning win over England.
Murrayfield was treated to a rare Scottish success over England, with Huw Jones scoring two tries and Finn Russell delivering a fine game.
Ireland will assess their performance after they survived a late scare to beat Wales 37-27 at the Aviva Stadium.
The Premiership saw its first draw of the season, while leaders Exeter Chiefs and Bath were winners by a solitary point on Saturday.
Ireland outscored Wales by five tries to three in Dublin to make it three Six Nations wins out of three.
Defending champions the Crusaders scored seven tries to get start their Super Rugby season with a hard-fought win over the Chiefs.
Scotland have not beaten England for a decade and Lee Mears does not expect them to put that right at Murrayfield.
Former England lock Simon Shaw says facing Scotland at Murrayfield will be a "very tough proposition" for the Six Nations holders.
England cannot afford to give Scotland the scent of victory in the closing stages at Murrayfield, says Martin Johnson.
Rob Harley's record 178th appearance for Glasgow Warriors was one to forget as they were beaten by Munster.
France ended their wait for a first win in the Six Nations, eventually easing past Italy 34-17 at the Stade Velodrome.