Robbie Henshaw and Dan Leavy have been ruled out of Ireland’s Six Nations clash with France, while Kieran Marmion and Ross Byrne have been added to the squad.
The versatile Henshaw misses out at the Aviva Stadium on Sunday for the third successive round due to a dead leg.
Flanker Leavy is still not ready to return after a spell on the sidelines with a calf strain.
Scrum-half Marmion and fly-half Byrne have been included, while Rob Herring gives another option at hooker along with captain Rory Best and Niall Scannell.
Joey Carbery (hamstring) and Andrew Conway (cramp) were also named in a 37-man squad as the defending champions eye a third successive win in Dublin.
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