Having suffered their first Premiership defeat of the season in their last away game, the Exeter Chiefs lost again at Northampton Saints.
Saracens had not suffered defeat since April, but they were soundly beaten by Exeter Chiefs to lose top spot in the Premiership.
Cobus Reinach and Luther Burrell scored intercept tries and Dan Biggar had a good outing at the tee in a comfortable win for Northampton.
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Danny Cipriani's hopes of catching Eddie Jones' eye again before the Six Nations appear to be slim after he suffered an injury blow.
Leicester Tigers have put their faith in Geordan Murphy to arrest their alarming slide after a run of eight consecutive defeats.
Eddie Jones has not been convinced by the in-form Danny Cipriani this season, but there are no hard feelings from the England fly-half.
RFU interim chief executive Nigel Melville does not believe scrapping relegation from the Premiership in the near future is a viable option.
A low-scoring draw at Bath was enough to lift Sale Sharks back off the bottom of the table, although they were frustrated after leading.
Defending champions Saracens have won each of their opening nine Premiership fixtures as they stayed perfect by beating Wasps 29-6.
Harlequins won an entertaining encounter with Exeter Chiefs to hand them their first defeat of the Premiership season.
South Africa and London Irish tweeted their best wishes to Naka Drotske, who was shot during a robbery in Pretoria.
Jack Nowell left the England camp with an injury last week and Exeter Chiefs have confirmed he suffered a torn hamstring.
Leicester Tigers almost took advantage of Saracens' ill-disciplined display, but fell short in a Premiership cracker at Welford Road.
There were wins in the Premiership on Saturday for Exeter, Sale and Wasps, the latter triumphing despite a stunning Bristol fightback.