Dan Biggar, James Davies and Jake Ball come into the Wales side as they eye revenge against England in Cardiff.
England's squad are aware the hard work in preparation for the World Cup in Japan has just started, according to head coach Eddie Jones.
Ben Te'o was surprisingly left out of England's Rugby World Cup squad, but Eddie Jones would not go into specifics on the decision.
Eddie Jones found room for wing Ruaridh McConnochie but Ben Te'o misses out on a place in the 31-man party for Japan.
England want to create their own legacy, says Billy Vunipola, who has no doubt Eddie Jones' side are over their 2015 World Cup frustration.
England head coach Eddie Jones took a swipe at the governing body six weeks before the Rugby World Cup over the tackle laws.
Wales head coach Warren Gatland had injury worries to contend with following a 33-19 World Cup warm-up defeat to England at Twickenham.
England were too good for a strong Wales side at Twickenham, where Gareth Anscombe and Tom Curry sustained injury blows.
We take a look at the heaviest defeats New Zealand have suffered following their 47-26 loss to Australia in the Rugby Championship.
Joe Cokanasiga, Jonathan Joseph and Lewis Ludlam have come into the England team due to a trio of injuries.
Eddie Jones has given some potential Rugby World Cup bolters a chance to show what they can do against Wales.
England start their Rugby World Cup preparation when they take on Wales on Sunday, and four players have been cut from Eddie Jones' squad.
Brad Shields has been sent for tests on a foot injury, with Alex Dombrandt called up to the England training camp in his place.
Joe Marchant is among the 38 players who have made the trip to Italy as England step up their preparations for the Rugby World...
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Omnisport looks at England's World Cup wins – and none have been straightforward.
Joe Marler has been named in Eddie Jones' 35-man Rugby World Cup training squad after indicating he was ready to return to England duty.