Billy Vunipola will take more motivation from England's response to the 2015 Rugby World Cup than from the disappointment.
Jack Nowell's versatility could be put to the test after Eddie Jones revealed the 25-year-old may feature for England in the pack.
Owen Farrell can thrive as captain in the absence of Dylan Hartley as England begin their Six Nations campaign against Ireland.
Owen Farrell will be England's sole captain against Ireland, with Dylan Hartley unavailable for the start of the Six Nations due to injury.
Ahead of the Six Nations, George Ford says he will always prioritise team success over his own battle with Owen Farrell for selection.
Wales are set to have Taulupe Faletau available for the Six Nations, while Jonathan Joseph may be available for England.
Three weeks before the start of the Six Nations, Sam Underhill has been ruled out of the tournament in a significant blow to England.
After four weeks out, England fly-half Danny Cipriani is back for Gloucester as they take on Munster on Friday.
Mark Wilson has signed a new four-year contract with Newcastle Falcons after some brilliant displays for England in November.
England's Sam Underhill will undergo a specialist review after suffering ankle ligament damage and could miss the start of the Six Nations.
Eddie Jones has not been convinced by the in-form Danny Cipriani this season, but there are no hard feelings from the England fly-half.
England lock Marto Itoje will be fit in time for the Six Nations, despite his recent knee injury, according to Saracens boss Mark McCall.
Saracens will be without Maro Itoje for "a number of weeks" after the lock picked up a knee problem on England duty.
Jack Nowell left the England camp with an injury last week and Exeter Chiefs have confirmed he suffered a torn hamstring.
Referee Angus Gardner concedes he made the wrong decision over Owen Farrell's contentious challenge on South Africa's Andre Esterhuizen.
England were dumped out of the Rugby World Cup early on home soil three years ago, but Sam Burgess is not accepting the blame.