Consistency of performance is what England have been lacking in the Six Nations, according to World Cup-winning captain Martin Johnson.
Mako Vunipola could play for Saracens this weekend, but England were advised not to take any risks following the prop's trip overseas.
Saracens have clarified Mako Vunipola has not been in self-isolation and is free to play Leicester Tigers this weekend.
Experienced duo Dan Biggar and Liam Williams are on course to be fit for Wales' showdown with England at Twickenham.
Initially ruled out of the Wales Six Nations game for "medical reasons", England confirmed Mako Vunipola is in self-isolation.
England will not have Mako Vunipola back to face Wales, with the prop ruled out for the Six Nations encounter at Twickenham.
Ireland's clash with Italy in Dublin is the only Six Nations match to be postponed due to the coronavirus.
England prop Mako Vunipola features in their 34-man squad ahead of the game with Wales, with Jack Maunder called up.
Absent for the opening three matches of the Six Nations, Anthony Watson is back in the mix for England this week.
England were quick out of the blocks against Ireland and Owen Farrell insists the team are happy with how things are "in-house".
Ireland were beaten 24-12 at Twickenham, with head coach Andy Farrell left to concede that England were much the better side.
Eddie Jones' team selection for England's crunch Six Nations clash with Ireland raised eyebrows, but his side responded in style on Sunday.
Ireland have been forced into a late change to their team to play England, with Devin Toner in for Iain Henderson.
Lewis Moody was impressed by England's grit and determination in the win over Scotland but says Ireland will provide a far sterner test.
World Cup winner Lewis Moody says Ellis Genge would be in his starting line-up to face Ireland with Mako Vunipola unavailable.
A mouthwatering round three of the Six Nations could be pivotal in a battle for the title that appears to be wide open.