The Stormers and the Bulls suffered disappointing home defeats in Super Rugby, with the Blues and the Jaguares emerging triumphant.
The Hurricanes proved far too strong for the Sunwolves in Super Rugby on Saturday, while the Sharks beat the Reds.
Ryan Baird and Dave Kearney both scored hat-tricks as Conference A leaders Leinster routed Glasgow Warriors on Friday.
Billy Twelvetrees contributed 12 points for Gloucester, but Sale Sharks held on for another Premiership victory.
After three consecutive defeats to start the Super Rugby season, the Waratahs finally got off the mark on Friday.
The IRFU has confirmed the postponement of Ireland versus Italy in the interest of public health.
Absent for the opening three matches of the Six Nations, Anthony Watson is back in the mix for England this week.
Cian Healy will miss the remainder of the Six Nations after the prop was injured during Ireland's loss to England.
Josh Adams will miss the games against England and Scotland as he requires surgery on the ankle he injured against France.
The Ospreys have turned to Toby Booth to take over as head coach when he finishes his assignment with Harlequins.
Wales full-back Liam Williams has joined the Scarlets ahead of schedule, while Rhys Webb joined Bath ahead of a move to Ospreys.
Former New Zealand prop Ben Franks says the end of this season will be the right time to end his illustrious career.
Ardie Savea says a move to either Sydney Roosters or Melbourne Storm are options that appeal to the All Blacks flanker.
More Italian sporting fixtures have been delayed by the coronavirus, with Zebre & Benetton Treviso seeing matches postponed.
Southern Kings and Benetton Treviso both fell short on Welsh soil as Scarlets and Cardiff Blues earned Pro14 wins.
Lyon and Toulouse were both winners in Sunday's Top 14 action, with Patricio Fernandez impressing for the former.