Premiership champions Saracens are through to the last eight of the European Champions Cup after beating Lyon on Sunday.
Wales are set to have Taulupe Faletau available for the Six Nations, while Jonathan Joseph may be available for England.
Joey Carbery, Rory Scannell, Keith Earls and Andrew Conway were among the tries as Munster overpowered Gloucester.
Returning to action after a broken arm proved an anxious experience for Saracens' Billy Vunipola, who is steadily regaining his poise.
After four weeks out, England fly-half Danny Cipriani is back for Gloucester as they take on Munster on Friday.
Danny Cipriani's hopes of catching Eddie Jones' eye again before the Six Nations appear to be slim after he suffered an injury blow.
Ireland will likely have to play three Six Nations matches without Iain Henderson after he underwent thumb surgery.
Back-to-back wins over Newcastle Falcons have Edinburgh closing in on a quarter-final place in the European Champions Cup.
Ulster and Exeter Chiefs enhanced their chances of qualifying for quarter-finals of tEurope's premier club rugby competition on Friday.
Nicolas Chauvin tragically passed away this week and Stade Francais have made tickets for their next match free as they pay their respects.
England lock Marto Itoje will be fit in time for the Six Nations, despite his recent knee injury, according to Saracens boss Mark McCall.
Premiership leaders Saracens made it three wins from three in the European Champions Cup after victory over Cardiff Blues on Sunday.
There were wins for Gloucester, Toulon and Leinster in the European Champions Cup on Saturday.
There were wins for Ulster and Edinburgh over the Scarlets and Newcastle Falcons in the European Champions Cup on Friday.
Saracens will be without Maro Itoje for "a number of weeks" after the lock picked up a knee problem on England duty.
After helping Ireland enjoy a dominant 2018, Johnny Sexton was named the World Rugby Player of the Year.