London Irish will make an immediate return to the Championship after Worcester Warriors eased to a crushing victory of Harlequins.
Bath's hopes of finishing in the top six are all but over after losing to Saracens, who guaranteed a place in the semi-finals.
Exeter Chiefs are assured of a top-four finish in the Premiership after scoring six tries in an emphatic win over Gloucester.
Exeter Chiefs have announced the signing of Alex Cuthbert from next season, the Wales winger signing a three-year deal.
Exeter Chiefs moved 11 points clear at the top of the Premiership after a dramatic victory over Bath at the Recreation Ground.
Exeter Chiefs boosted their Premiership title defence with a victory over Saracens that saw the beaten side fall to third in the table.
The Premiership saw its first draw of the season, while leaders Exeter Chiefs and Bath were winners by a solitary point on Saturday.