Munster ended a four-game losing streak against Leinster with a 26-17 triumph on Saturday, while Edinburgh retained the 1872 Cup.
Connacht scored four tries but still lost out to Leinster, who rallied from 17 points down to triumph in dramatic circumstances.
Stephen Jones and Jonathan Humphreys will be on the coaching staff in a new era for Wales under Wayne Pivac.
Saracens battled past Cardiff Blues to stay top of Pool 3, while Toulouse came out on top in an entertaining clash with Wasps.
Leinster delivered a fantastic performance against the Ospreys, racking up 52 points as seven different players crossed for tries.
Stuart Hogg said the time has come to challenge himself in a different environment after nine seasons with Glasgow Warriors.
Glasgow Warriors stretched their lead at the top of Conference A to nine points thanks to Nikola Matawalu's hat-trick against Ospreys.
Munster overturned a 14-point deficit to beat Glasgow Warriors thanks to Rory Scannell's monster penalty with the final play.
Maxime Medard's late try proved crucial as Toulouse beat European Champions Cup holders Leinster on Sunday.
Stuart Hogg's contract expires next year and the Scotland full-back is weighing up his options.
Newcastle Falcons' return to Europe's elite club competition was worth the wait as they beat stunning Toulon at Stade Mayol.
Connacht finally secured an away derby win at Ulster, taking advantage of Matthew Rea's dismissal early in the second half.
Leinster's Pro14 title defence continued with a fourth win in five, with Glasgow Warriors and the Ospreys matching that return on Saturday.
The Southern Kings claimed a first Pro14 win of the season and consigned Glasgow Warriors to a first loss in Port Elizabeth.
Glasgow Warriors are the only club to have won each of their opening three fixtures after overcoming the Cheetahs.
John Cooney kicked a last-gasp penalty for the second successive week as Ulster left it late to beat Pro14 rivals Edinburgh.