Saracens were on the brink of a second defeat in three Premiership games but they battled back to defeat London Irish.
Northampton Saints and Gloucester followed up narrow away wins on the opening weekend by easing to home successes in the Premiership.
Northampton Saints claimed a win over the reigning champions at Allianz Park on the opening weekend of the Premiership season.
Munster, Racing 92 and the Ospreys will take on holders Saracens in the pool stage of the 2019-20 European Champions Cup.
Danny Cipriani and Alex Goode have been outstanding this season and Martin Johnson feels they could yet board the plane to Japan.
While out of the England picture, Danny Cipriani's Gloucester form has seen him named the Premiership's outstanding player.
Having spent six successive years in the top flight, Newcastle Falcons were relegated from the Premiership on Saturday.
Gloucester returned to the play-offs for the first time since 2011 despite losing to Worcester Warriors, who sealed Premiership safety.
Worcester Warriors and Bristol Bears eased their relegation fears, leaving Newcastle Falcons needing a great escape to avoid the drop.
Northampton Saints lost an 11-try thriller to Gloucester, who saw Mark Atkinson flourish with a hat-trick at Franklin's Gardens.
Success with Gloucester, rather than an England recall, is Danny Cipriani's top priority after signing a three-year extension at Kingsholm.
Danny Cipriani has been linked with a host of Premiership and Top 14 clubs, but the fly-half will be staying at Gloucester.
Two tries from Will Skelton helped Premiership title hopefuls Saracens fight back to beat Harlequins 27-20 at London Stadium on Saturday.
Having suffered defeat to Bristol last time out, Gloucester responded in emphatic fashion with a resounding away win over Harlequins.
Gloucester let Friday's Premiership match slip through their fingers late on at Bristol Bears.
Ben Morgan's brace led Gloucester to another big victory as they fended off a fast-finishing Saracens.