Siya Kolisi will lead an unchanged South Africa XV against Wales as the Springboks look to finish 2018 on a high.
David Pocock has recovered from a neck injury to take his place in Australia's team to take on England.
Joe Schmidt has made 14 changes to the Ireland side that beat New Zealand for this weekend's Test against the United States.
Liam Williams starts at full-back, with Wales largely returning to the team that beat Australia against South Africa this weekend.
Dylan Hartley is set to break the record for Test appearances at Twickenham, but the co-captain will start on the bench.
Beauden Barrett, Damian McKenzie, captain Kieran Read and Ardie Savea are the only players to keep their places in the All Blacks side.
Gregor Townsend has again shaken up his Scotland team, making eight changes for the clash with Argentina.
Wales will be without Leigh Halfpenny for the visit of South Africa to Cardiff on Saturday.
Eddie Jones thought "here we go again" when he heard David Pocock may not be feature in the Cook Cup showdown.
Sean O’Brien had surgery on his broken arm and will be out for between eight and 12 weeks, Leinster revealed on Monday.
England will complete their 2018 programme with a clash against Australia at Twickenham.
Steve Hansen declared that Ireland are the number one team in the world and favourites for the World Cup after beating the All Blacks.
Kieran Read said New Zealand could not have thrown any more at Ireland, but must learn lessons from their Dublin defeat.
France secured their first win since March, Teddy Thomas helping himself to a double with Gael Fickou impressing on his return.
New Zealand failed to score a try in Dublin, underlining Ireland's remarkable commitment in defence as they defeated the world champions.
For the first time in their history Ireland beat New Zealand on home soil, toppling the world champions with a fine performance in Dublin.