Fourteen-man France saw their Grand Slam ambitions dissipate against Scotland on a tough afternoon at Murrayfield.
Joe Marler escaped punishment from the officials on Saturday in an incident that seemingly left Alun Wyn Jones bemused.
Sloppy early play and second-half indiscipline cost Wales against England, says Alun Wyn Jones.
England maintained their Six Nations title bid with victory against Wales, aided by a scoring return for wing Anthony Watson.
France head to Murrayfield scenting a Grand Slam and a first Six Nations title in a decade, while wounded Wales face England.
Wales have lost back-to-back Six Nations clashes and will face England at Twickenham on Saturday with a side showing four changes.
Italy have had a second Six Nations match postponed due to the coronavirus, with doubts over whether the tournament will be completed.
Mark Wilson and Anthony Watson replace Sam Underhill and Jonathan Joseph respectively in the England side to face Wales.
Mako Vunipola could play for Saracens this weekend, but England were advised not to take any risks following the prop's trip overseas.
Experienced duo Dan Biggar and Liam Williams are on course to be fit for Wales' showdown with England at Twickenham.
Fly-half Finn Russell will play no part in the Six Nations, but could make his Scotland return later this year.
The IRFU has confirmed the postponement of Ireland versus Italy in the interest of public health.
Absent for the opening three matches of the Six Nations, Anthony Watson is back in the mix for England this week.
Cian Healy will miss the remainder of the Six Nations after the prop was injured during Ireland's loss to England.
Wales full-back Liam Williams has joined the Scarlets ahead of schedule, while Rhys Webb joined Bath ahead of a move to Ospreys.
Wales look highly unlikely to retain their Six Nations title after a loss to France, but Wayne Pivac felt they were hard done by.