Johnny Sexton and Jordan Larmour have been joined by uncapped number eight Caelan Doris in Ireland's team to face Scotland.
The mercurial Finn Russell has been punished for a breach of team protocol just nine days before Scotland's first Six Nations game.
Johnny Sexton expects to lead Ireland against Scotland in Dublin and Jordan Larmour is expected to be in contention.
Andy Farrell has opted to add more depth at centre to Ireland's Six Nations squad in the form of Stuart McCloskey.
Andy Farrell has called up five uncapped players into his first Ireland squad, with Johnny Sexton confirmed as the team's captain.
Joey Carbery has suffered another injury blow and will play no part in Ireland's bid to regain the Six Nations title.
Ireland have named a 45-man squad to train in Dublin that omits Rob Kearney, Jordi Murphy, Sean Cronin, Jack Carty and Kieran Marmion.
Lyon are reportedly targeting Ireland fly-half Johnny Sexton, but Leinster insist there has been no suggestion he will leave the province.
Leinster head coach Leo Cullen is unsure how long fly-half Johnny Sexton will be out of action.
Rory Best will bring his rugby career to an end by captaining Eddie Jones' Barbarians side against Fiji at Twickenham on Saturday.
Six of the top seven teams in the world rankings will start life with a new coach following the Rugby World Cup.
England head coach Eddie Jones will deploy the same starting XV that beat New Zealand in last week's semi-final.
Outgoing New Zealand head coach Steve Hansen has made seven changes for Friday's bronze medal match as stars prepare to depart.
Owen Farrell will move back to outside centre, with George Ford at fly-half for England's Rugby World Cup semi-final against New Zealand.
Scott Barrett is the only change to the starting All Blacks team who crushed Ireland in the quarter-finals as they prepare to face England.
After New Zealand thrashed Ireland in Tokyo, Steve Hansen highlighted the value of their experience winning competitions.