Beauden Barrett will make history if he is named the best player in the world again, but he has some strong competition.
Manu Tuilagi has suffered yet another injury blow, a groin problem ruling him out of the showdown with South Africa.
Both Ireland and Italy are lacking several key men for this weekend's Test meeting in the United States.
Australia will be determined to end their tour with a morale-boosting win over England after a barren run against their rivals.
Injuries have ravaged England's forward pack, but Eddie Jones is excited and confident heading into the South Africa Test.
Rassie Erasmus has made seven changes to his South Africa side, bringing in Ivan van Zyl as well as regulars including Warren Whiteley.
Wales have named the team that will take on Scotland in their opening November international, with Jonathan Davies back in the fold.
Eddie Jones has named his England side to face South Africa on Saturday, with Owen Farrell and Dylan Hartley named co-captains.
New Zealand named eight Test debutants for their clash against Japan in Tokyo.
Sara Cox will take charge as Wasps face Northampton Saints, becoming the first female referee in the Premiership Rugby Cup.
Stuart McInally captains Scotland again against Wales, but there are numerous changes to the side that beat Argentina.
Gethin Jenkins, Wales' most capped player, will retire from rugby this weekend.
Fergus McFadden faces a lengthy spell on the sidelines after suffering a high-grade tear of his hamstring in training.
Allan Alaalatoa believes Australia can become a force again after signing a new deal until the 2023 Rugby World Cup.
Will Carling is back in the England fold, the retired ex-captain taking on a leadership role under coach Eddie Jones.
James Lang and Darcy Graham will be involved for Scotland in November after a series of injuries ahead of the upcoming Tests.