Northampton Saints lost an 11-try thriller to Gloucester, who saw Mark Atkinson flourish with a hat-trick at Franklin's Gardens.
Bristol Bears and Northampton Saints were no match for La Rochelle and Clermont in the European Challenge Cup quarter-finals.
England captain Dylan Hartley missed the Six Nations with a knee injury, but Northampton Saints expect him back this season.
Leicester Tigers had no response after Northampton Saints raced clear in the first half of Friday's Premiership grudge match.
Brett Connon held his nerve with a late penalty to give Newcastle victory at Wasps, while Exeter also did the Falcons a favour.
Saracens eased past Northampton Saints but table-topping Exeter Chiefs had to repel a second-half rally from Sale Sharks.
Northampton Saints legend Tom Wood has extended his contract with the Premiership club.
After playing his whole career in rugby union, Luther Burrell will line up for rugby league side Warrington Wolves later this year.
Leicester Tigers limped to defeat at Saracens, meaning the victors once again sit top of the Premiership.
Owen Franks is looking forward to a new adventure in the Premiership after agreeing to join Northampton Saints.
Northampton scored 17 tries in a record victory as they beat Timisoara Saracens 111-3 to reach the European Challenge Cup quarter-finals.
Wasps won for only the second time since September with a fit-again Joe Launchbury back in the side.
Having suffered their first Premiership defeat of the season in their last away game, the Exeter Chiefs lost again at Northampton Saints.
Cobus Reinach and Luther Burrell scored intercept tries and Dan Biggar had a good outing at the tee in a comfortable win for Northampton.
Timisoara Saracens have been punished for not doing enough to try to get the game against Northampton Saints to go ahead last Saturday.
There were wins for the Ospreys, Sale Sharks and Clermont Auvergne in the European Challenge Cup on Saturday.