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Grand Slam hopefuls France have made two changes for their match with Scotland, who have Fraser Brown poised to win his 50th cap.
England overlook Mako Vunipola as a coronavirus precaution, yet he will play for Saracens against Leicester Tigers.
England are expecting a tough battle against Wales and Eddie Jones believes last year's loss in Cardiff provides perfect motivation.
Wales boss Wayne Pivac expects a "big performance" against England after stepping up intensity in training, epitomised by Alun Wyn Jones.
France head to Murrayfield scenting a Grand Slam and a first Six Nations title in a decade, while wounded Wales face England.
Lewis Moody was impressed by England's grit and determination in the win over Scotland but says Ireland will provide a far sterner test.
A mouthwatering round three of the Six Nations could be pivotal in a battle for the title that appears to be wide open.
Alessandro Zanni comes back in for Dean Budd in Italy's only change for their clash with Scotland.
Scotland, who are yet to score a try in this year's Six Nations, have made three changes to their XV to face Italy in Rome.
Arthur Vincent and Jayden Hayward come into the France and Italy starting line-ups respectively for the match in Paris.
Scotland have resisted the temptation to make sweeping changes for the Calcutta Cup contest with England.
Wales have rewarded Nick Tompkins with a first start for the Six Nations clash against Ireland in Dublin.
Eddie Jones has rung the changes for England's crucial Calcutta Cup contest with Scotland at Murrayfield.
Finn Russell will miss his second straight game when Scotland take on England, but Blair Kinghorn spoke of the squad's confidence.
England were humbled by France in their Six Nations opener and Eddie Jones could be set to make changes for the clash with Scotland.
England must show they have a mature mentality if they are to defeat Scotland and clinch the Calcutta Cup, says Courtney Lawes.
