Ireland travel to Cardiff on Saturday for a Rugby World Cup warm-up match, with Josh Navidi set to captain Wales for the first time.
New Zealand host Australia at fortress Eden Park looking for a first win in three Tests to retain the Bledisloe Cup.
Australia will be looking to pull off a shock by beating their trans-Tasman rivals in the Bledisloe Cup opener in Perth.
Lining up as South Africa captain for the first time in New Zealand on Saturday, Duane Vermeulen aims to lead by example.
James O'Connor has already impressed on his return to Australia training and Michael Hooper is keen to see him deliver on the pitch, too.
In the second round of the Rugby Championship, South Africa will attempt to achieve a feat against New Zealand they have managed just twice.
Sevu Reece is among the Rugby World Cup hopefuls who will look to make their mark in a shortened Rugby Championship.
Argentina will have to produce something special to claim a historic win over New Zealand in their Rugby Championship opener.
Injury has denied Ryan Crotty a Crusaders farewell after he was ruled out of Saturday's Super Rugby final against Jaguares.
Twenty-eight of the scheduled starters in Saturday's European Champions Cup final have represented their country at international level.
As two European heavyweights lock horns in the Champions Cup final, we look at the key battles that will decide Leinster versus Saracens.
Leinster and Saracens have both named teams packed with Champions Cup experience for Saturday's final in Newcastle.
Saracens will attempt to deny Leinster a record fifth European Champions Cup - here are the best pre-match Opta numbers.
Johnny Sexton will not be risked for Leinster's Champions Cup quarter-final, but Maro Itoje and Stuart Hogg are set to return this weekend.
Jacques Brunel recalled Wesley Fofana for the trip to Italy but the France centre has been ruled out late on due to injury.
Eddie Jones' claim that Wales look tired ahead of a decisive weekend in the Six Nations has been laughed off by Warren Gatland.