Wing Teddy Thomas put more pressure on Stade Francais coach Heyneke Meyer as Racing 92 came out on top in the Paris derby.
Racing 92 dominated the second half to beat Pau before La Rochelle were beaten by Toulon at Stade Mayol.
Despite seeing their try line breached for the first time this season, Lyon maintained a 100 per cent start to the season in the Top 14.
Toulon and Agen each won in the Top 14 on Sunday, with Racing 92 unable to complete a turnaround while Montpellier were outplayed.
Toulouse won the Top 14 last season but they have been beaten in each of their first two matches at the start of the 2019-20 campaign.
La Rochelle finished behind Racing 92 in the Top 14 regular season but dumped the Paris club out of the play-offs on Friday.
Perpignan suffered a 23rd loss in 25 Top 14 games as Louis Dupichot and Simon Zebo scored hat-tricks in Racing 92’s 52-14 victory.
It promises to be an enthralling climax to the battle for Top 14 play-off spots after Stade Francais claimed a derby win over Racing 92.
Top 14 leaders Toulouse enjoyed a fine day as several rivals were beaten amid a series of dramatic finishes.
Sofiane Guitoune’s 77th-minute try carried Toulouse past Clermont Auvergne as the top two in the table served up a Sunday treat.
Clermont Auvergne had to settle for a draw against Racing 92, while Lyon held on to beat Pau in a thrilling day of Top 14 action.
Toulouse played almost an hour with 14 men but were still able to beat Racing 92 in a magnificent European Champions Cup quarter-final.
Toulouse are now unbeaten in 14 Top 14 matches after grinding it out at La Rochelle, while Racing 92 got the better of Bordeaux.
Leicester Tigers have confirmed England centre Manu Tuilagi has signed a new deal with the Premiership club.
Kieran Read had been linked with Racing 92 and a Premiership switch, but said it was a “pretty straightforward” decision to move to Japan.
Lyon claimed a third successive win and are breathing down Clermont’s necks after beating them at Matmut Stade de Gerland,