Italy captain Sergio Parisse will make his 68th Six Nations appearance when the Azzurri face England on Saturday.
Ali Price replaces captain Greig Laidlaw as one of four changes to the Scotland side to take on leaders Wales.
Eddie Jones has made five changes to the England team to take on Italy, Joe Cokanasiga and Ben Te'o among the players coming in.
The Six Nations and Rugby Championship could introduce promotion and relegation as part of planned changes to the international game.
Kieran Marmion and Ross Byrne have been named in the Ireland squad ahead of the clash with France, but Robbie Henshaw and Dan Leavy...
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Maro Itoje limped out of England training and Charlie Ewels has been called up as cover for the lock.
Joey Carbery and Andrew Conway could feature against France this weekend, but Robbie Henshaw and Dan Leavy may be absent.
Warren Gatland wants Wales to focus on winning the Six Nations, but says talk of an Ospreys-Scarlets merger has had an impact on players.
Cory Hill's ankle injury has given Adam Beard an opportunity to come back into the Wales starting line-up at Murrayfield.
Scott Hastings says the onus is on Greig Laidlaw and other senior Scotland players to step up when they lock horns with Wales.
Jacques Brunel has unsurprisingly stuck with the same 23 to take on the defending champions after an impressive display against Scotland.
Scotland will once more be without full-back Stuart Hogg when they take on Wales in the Six Nations this weekend.
British and Irish Lions duo Maro Itoje and Jonathan Joseph, as well as former skipper Chris Robshaw, have been called up by England.
Joe Schmidt says Johnny Sexton and Joey Carbery should recover from injuries in time to take on France in Dublin.
World Rugby's proposed changed to the international calendar have not gone down well with top players.
Cory Hill was injured while scoring a try which set Wales on their way to beating England in Cardiff and will not face Scotland...
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