Mako Vunipola and Chris Ashton are replaced by Ben Moon and Jack Nowell in England's starting line-up to take on Wales.
Josh Strauss has lost his passport, but the Scotland back row has been given the stamp of approval to travel to Paris.
England's Steve Borthwick has confirmed that Maro Itoje will be absent again when they travel to Wales on Saturday.
Wales are hopeful that Leigh Halfpenny and Dan Biggar will recover in time to face England in the Six Nations on Saturday.
Having played for Ulster last week, Iain Henderson has been named in the 34-man Ireland squad to face Italy as expected.
Having sustained a suspected concussion while playing for Top 14 at the weekend, Sergio Parisse will sit out Italy's clash with Ireland.
Morgan Parra and Camille Lopez's absence from France's Six Nations squad is a sporting decision and nothing more, says Jacques Brunel.
Finn Russell has not satsified the requirements of his graduated return-to-play protocol and will miss Scotland's clash with France.
The Irish Rugby Football Union (IRFU) has confirmed Leinster's Robbie Henshaw has extended his contract until June 2022.
Full-back Thomas Ramos will make his first start for France, who have a new half-back pairing for the Six Nations clash against Scotland.
Gregor Townsend has added six players to Scotland's squad ahead of the France Six Nations trip, but Stuart Hogg is out.
A minor calf strain means Chris Ashton will miss England's trip to face Wales in the Six Nations.
Following a head injury against Scotland, Johnny Sexton is fit again and in the running to play for Ireland in Italy.
Wales were dealt a blow on Friday as Leigh Halfpenny's expected comeback for the Scarlets did not come to fruition.
Eddie Jones sought to dismiss Wales' strong record in Cardiff ahead of England's Six Nations visit, but Neil Jenkins is not worried.
Ellis Genge was removed from training on Thursday, but Steve Borthwick does not think there will be any 'major consequences' for the prop.