Initially ruled out of the Wales Six Nations game for "medical reasons", England confirmed Mako Vunipola is in self-isolation.
England will not have Mako Vunipola back to face Wales, with the prop ruled out for the Six Nations encounter at Twickenham.
Ireland's clash with Italy in Dublin is the only Six Nations match to be postponed due to the coronavirus.
England prop Mako Vunipola features in their 34-man squad ahead of the game with Wales, with Jack Maunder called up.
Fly-half Finn Russell will play no part in the Six Nations, but could make his Scotland return later this year.
The IRFU has confirmed the postponement of Ireland versus Italy in the interest of public health.
Absent for the opening three matches of the Six Nations, Anthony Watson is back in the mix for England this week.
Cian Healy will miss the remainder of the Six Nations after the prop was injured during Ireland's loss to England.
Josh Adams will miss the games against England and Scotland as he requires surgery on the ankle he injured against France.
England were quick out of the blocks against Ireland and Owen Farrell insists the team are happy with how things are "in-house".
Ireland were beaten 24-12 at Twickenham, with head coach Andy Farrell left to concede that England were much the better side.
Eddie Jones' team selection for England's crunch Six Nations clash with Ireland raised eyebrows, but his side responded in style on Sunday.
Wales look highly unlikely to retain their Six Nations title after a loss to France, but Wayne Pivac felt they were hard done by.
France kept their Grand Slam hopes live with a famous win in Cardiff, but Romain Ntamack says they are not getting ahead of themselves.
Stuart Hogg, Chris Harris and Adam Hastings crossed as Scotland claimed their first win of the 2020 Six Nations by beating Italy.
Ireland have been forced into a late change to their team to play England, with Devin Toner in for Iain Henderson.