Eddie Jones confirmed Manu Tuilagi will not face Scotland, but is hopeful the centre will take on Ireland at Twickenham.
Tom Curry looks certain to continue at number eight for the foreseeable future and earned the backing of England coach Eddie Jones.
In-form Harlequins number eight Alex Dombrandt will play no part in the Calcutta Cup clash after being left out of England's squad.
Gregor Townsend said the door is open for Finn Russell to return to the Scotland squad, but he will not face England.
Ahead of crunch Six Nations matches with Wales and England, Ireland were dealt a blow with Garry Ringrose ruled out.
Man-of-the-match Gregory Alldritt said France were determined to show Eddie Jones they have fighting spirit in Paris.
New head coach Fabien Galthie believes France reaped the rewards of meticulous preparation for the Six Nations when they beat England.
England were made to pay for an error-strewn performance in Paris, where France enjoyed a winning start to the Six Nations.
After England coach Eddie Jones questioned their Test credentials ahead of the Six Nations clash, France let their rugby do the talking.
Captain Owen Farrell said there were no excuses for England after they were beaten by France in Paris.
Charles Ollivon led from the front with a double in his first game as captain as France beat England at the start of a...
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France produced a dazzling opening 40 minutes to lead England 17-0 in Paris, Vincent Rattez and Charles Ollivon both scoring tries.
Scotland were wasteful against Ireland on Saturday, with Stuart Hogg apologetic as he departed Dublin following a huge missed opportunity.
Josh Adams plundered a hat-trick in Wales' rout of Italy, much to the delight of his boss Wayne Pivac.
Johnny Sexton has played only three matches since the Rugby World Cup, but Andy Farrell saw an "outstanding" display from Ireland's captain.
Ireland were below their best on Saturday but gave new head coach Andy Farrell a winning start against Scotland.