Scrum-half Joe Simpson scored two first-half tries but Gloucester could not contain Toulouse after the break at Kingsholm.
Wing Teddy Thomas put more pressure on Stade Francais coach Heyneke Meyer as Racing 92 came out on top in the Paris derby.
Exeter Chiefs were in control at half-time, but Bristol Bears scored 20 points without reply in the second half to snatch a stunning win.
Munster were delighted to have Andrew Conway back in Pro14 action as he settled an all-Irish affair with Ulster.
Toulouse's contrasting home and away form continued as they defeated visitors and 2018-19 Top 14 final opponents Clermont Auvergne.
A looming points deduction would see Saracens facing a Premiership relegation battle this season, but they defeated Gloucester on Saturday.
Rob du Preez kicked 17 points while his brother Dan scored Sale Sharks' only try in a hard-fought 28-18 Premiership victory over Wasps.
Andrew Porter and Ronan Kelleher each crossed twice as Leinster maintained their 100 per cent record, while Edinburgh beat Dragons.
A late Harry Williams try proved decisive as Exeter Chiefs came from 14 points behind to overcome Worcester Warriors.
After succumbing to a thrashing against Edinburgh in their previous match, Scarlets narrowly beat Cheetahs in Pro14.
Saracens were on the brink of a second defeat in three Premiership games but they battled back to defeat London Irish.
South Africa dominated England to match New Zealand's tally of lifting the Webb Ellis Cup for a third time.
Taqele Naiyaravoro impressed again as Northampton maintained their winning start to the Premiership season on Friday.
Undefeated Leinster made light work of the Dragons as Glasgow Warriors thrashed Southern Kings 50-0 on Friday.
New Zealand put on a show in Steve Hansen's last game in charge, Ben Smith scoring two of their six tries in an emphatic...
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Saracens demonstrated their strength in depth with a victory at Welford Road, outscoring Leicester Tigers by three tries to one.