Stuart Hogg, Chris Harris and Adam Hastings crossed as Scotland claimed their first win of the 2020 Six Nations by beating Italy.
Australian Conference rivals the Brumbies and the Reds enjoyed big wins on Saturday, the leaders recovering from an outbreak of mumps.
Marland Yarde was in fine form as Sale Sharks went second in the Premiership table in style against Leicester Tigers.
Leinster became the first Pro14 side to win their first 12 league matches of a season after they overcame Ospreys on Friday.
Four tries in the first half helped the Crusaders cruise to a 33-13 triumph over the Highlanders in Super Rugby.
Racing 92 stretched their Top 14 winning run to five matches with a dramatic defeat of Toulouse.
Henry Purdy and Lewis Thiede touched down within two minutes of one another to see Bristol Bears past Northampton Saints.
The Reds squandered a promising lead in Argentina as the Jaguares claimed their second win of the season.
The Ospreys claimed only their second Pro14 win over the season at the expense of high-flying Ulster in a stormy Swansea.
Lyon surrendered first place in Top 14 as they lost away to Bordeaux-Begles, who won a contest that was closer than the scoreline suggests.
London Irish handled challenging conditions impressively to win at Harlequins, while champions Saracens were too good for Sale Sharks.
The Brumbies looked to be heading for victory following a Folau Fainga'a hat-trick, but they were unable to hold off the Highlanders.
Stuart Hogg was among the scorers on his Exeter Chiefs return as Gloucester were beaten at home.
It was a record-breaking outing for Munster in Pro14 action on Friday, while Glasgow Warriors were also big winners.
Andrew Kellaway scored two tries against his former club, the Waratahs, to give the Rebels a valuable win in Melbourne.
France claimed a bonus-point victory over Italy to make it two wins from two in the Six Nations.