Hamish Watson has dropped out of Scotland's Six Nations squad with a hand injury, while four players have been called up.
Seven uncapped players feature in Scotland's squad for the Six Nations, with three of those selected at hooker.
Scotland's work ethic and persistence pleased Gregor Townsend as they ended 2018 with victory over Argentina at Murrayfield.
Greig Laidlaw kicked three penalties before Sean Maitland's try as Scotland beat Argentina 14-9 at Murrayfield.
Gregor Townsend has again shaken up his Scotland team, making eight changes for the clash with Argentina.
Handre Pollard scored 18 points as South Africa became only the second side in 12 matches to beat Scotland at Murrayfield.
With Faf de Klerk on club duty with Sale Sharks, Embrose Papier will make his first South Africa start on Saturday.
Gordon Reid will make his first Scotland appearance since March as one of six changes for their clash with South Africa.
Warren Whiteley's calf injury could keep him out of South Africa's clash with Scotland, but Eben Etzebeth may return.
Gary Graham was called up to the England Six Nations squad this year, but is set to win his first international cap for Scotland.
Stuart Hogg said the time has come to challenge himself in a different environment after nine seasons with Glasgow Warriors.
Having been behind as half-time approached, Scotland ultimately thrashed Fiji with Tommy Seymour scoring three of their eight tries.
The return of Stuart Hogg slightly eases Scotland's concerns, while Greig Laidlaw and Finn Russell also start against Fiji.
Gregor Townsend has called up half a dozen new players to the Scotland squad after various injuries at the weekend.
Warren Gatland saw room for improvement but was encouraged by the way Wales saw off Scotland to win the Doddie Weir Cup.
Wales started their November internationals with victory over Scotland, Jonathan Davies scoring on his return from a long injury lay-off.