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Warren Whiteley's calf injury could keep him out of South Africa's clash with Scotland, but Eben Etzebeth may return.
Gary Graham was called up to the England Six Nations squad this year, but is set to win his first international cap for Scotland.
Stuart Hogg said the time has come to challenge himself in a different environment after nine seasons with Glasgow Warriors.
Having been behind as half-time approached, Scotland ultimately thrashed Fiji with Tommy Seymour scoring three of their eight tries.
The return of Stuart Hogg slightly eases Scotland's concerns, while Greig Laidlaw and Finn Russell also start against Fiji.
Gregor Townsend has called up half a dozen new players to the Scotland squad after various injuries at the weekend.
Warren Gatland saw room for improvement but was encouraged by the way Wales saw off Scotland to win the Doddie Weir Cup.
Wales started their November internationals with victory over Scotland, Jonathan Davies scoring on his return from a long injury lay-off.
Australia will be determined to end their tour with a morale-boosting win over England after a barren run against their rivals.
Wales have named the team that will take on Scotland in their opening November international, with Jonathan Davies back in the fold.
Stuart McInally captains Scotland again against Wales, but there are numerous changes to the side that beat Argentina.
James Lang and Darcy Graham will be involved for Scotland in November after a series of injuries ahead of the upcoming Tests.
Gregor Townsend has named a 40-man squad for Scotland's upcoming Tests, with a swathe of big names returning to the fold.
Stuart Hogg's contract expires next year and the Scotland full-back is weighing up his options.
Stuart Hogg has been ruled out for 10 to 12 weeks, meaning the Glasgow Warriors star is set to miss all four of Scotland's November Tests.
After negotiating an exit from his contract with Scotland, Dan McFarland will take the head coaching reins at Ulster.
