Scotland's hopes of retaining the Calcutta Cup have been boosted by the return of Sam Skinner for Saturday's clash with England.
Saracens scrum-half Ben Spencer has been added to England's squad after Dan Robson was ruled out due to illness.
Tommy Seymour, Blair Kinghorn and Stuart Hogg will miss Scotland's final Six Nations match, while France will also be without two players.
Maro Itoje will be unable to aid England's bid to win the Six Nations after injury ruled him out of the Scotland game.
Gregor Townsend was left to reflect on a missed opportunity after Scotland failed to derail Wales' quest for a Grand Slam.
Scotland dominated the second half at Murrayfield and Warren Gatland admitted his Wales side got "a little bit lucky" as they prevailed.
Victory over Ireland in the final round of the Six Nations would secure a Grand Slam for Wales after Warren Gatland's men overcame Scotland.
Scott Hastings says it is time Scotland did themselves justice when they face Six Nations leaders Wales at Murrayfield.
The fourth round of fixtures in the 2019 Six Nations sees Wales visit Scotland, England take on Italy and Ireland host France.
Ali Price replaces captain Greig Laidlaw as one of four changes to the Scotland side to take on leaders Wales.
Cory Hill's ankle injury has given Adam Beard an opportunity to come back into the Wales starting line-up at Murrayfield.
Scott Hastings says the onus is on Greig Laidlaw and other senior Scotland players to step up when they lock horns with Wales.
Scotland will once more be without full-back Stuart Hogg when they take on Wales in the Six Nations this weekend.
Having been thrashed by England last time out, a much-changed France side produced a fine showing to down Scotland in Paris.
The third round of fixtures in the 2019 Six Nations sees Wales host England, Scotland visit France, and Ireland head to Italy.
Pete Horne is preferred to Adam Hastings in Scotland's starting line-up for their clash with France in Paris.