After overcoming a serious knee injury, hooker Leonardo Ghiraldini has been included in Conor O’Shea’s 31-man squad.
As Italy ended the Six Nations without a victory, having squandered big chances against France, Conor O’Shea acknowledged their hurt.
Italy captain Sergio Parisse will make his 68th Six Nations appearance when the Azzurri face England on Saturday.
Having sustained a suspected concussion while playing for Top 14 at the weekend, Sergio Parisse will sit out Italy’s clash with Ireland.
Wales made it two from two in the 2019 Six Nations but captain Jonathan Davies was not wholly satisfied with their display against Italy.
Italy were well beaten by Scotland, but Greig Laidlaw knows his team must ensure they perform for the full 80 minutes.
Scotland were comfortable winners over Italy in their Six Nations opener, with Blair Kinghorn registering his first international hat-trick.
Italy captain Sergio Parisse has now played in more Six Nations matches than any other player, after starting against Scotland.
Italy’s one change to face Scotland sees Jake Polledri set for an international debut, while Sergio Parisse reaches another landmark.