Eben Etzebeth has not played since November and has suffered a setback in his recovery from a shoulder injury.
Duane Vermeulen had been linked with a move to Bath, but he will continue his career in Japan after leaving Toulon.
After ending his worst stretch as coach, Eddie Jones believes England are back on track to challenge at the World Cup.
England's five-Test losing streak is over after they overcame South Africa 25-10 at Newlands.
Rassie Erasmus expects Danny Cipriani to test the Springboks as they attempt to complete a 3-0 whitewash in Cape Town.
Eddie Jones remains the right man to lead England into the Rugby World Cup, says Lewis Moody.
World Cup winner Lewis Moody has called on the RFU to ease England's workload to ensure they are competitive in Japan next year.
Schalk Brits has not played for the Springboks since 2015, but the veteran hooker is set to come off the bench against England.
George Ford has been dropped for the third Test against South Africa, with Danny Cipriani finally getting his chance from the start.
Eddie Jones is under pressure after a dire run of England's results, but he sees significant success on the horizon.
England will be without Billy Vunipola for the final Test against South Africa, and Duane Vermeulen says it is a big loss.
England have confirmed Billy Vunipola re-fractured his right arm during the second Test against the Springboks.
South Africa made a slow start against England but, to Rassie Erasmus' delight, came roaring back to clinch the series.
England let a 12-0 lead slip to lose to South Africa on Saturday, leading captain Owen Farrell to conclude that his side lack composure.
It was not a comeback on the same scale as the first Test, but South Africa fought back from 12-0 down to beat England...
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England continue to believe in themselves ahead of their second Test against South Africa, according to captain Owen Farrell.